Neutrophil to lymphocyte ratio as predictor of outcomes in secondary perforation peritonitis
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- To evaluate the relationship between NLR and mortality within hospital stay of patients with secondary perforation peritonitis
研究概览
简要总结
Perforation peritonitis is a common surgical emergency in India, often caused by peptic ulcer perforation, appendicular perforation, trauma, tuberculosis, or enteric perforations. It can lead to severe complications such as sepsis, septic shock, pneumonia, surgical site infections, and organ failure, with a high morbidity rate (~50%) and mortality rate (10–30%). The neutrophil-to-lymphocyte ratio (NLR) is an easily available and cost-effective marker of systemic inflammation, helping predict infection, sepsis, and postoperative complications. NLR, influenced by various factors like anemia, stress, and chronic diseases, is more reliable than CRP in assessing inflammation. This study aims to evaluate NLR as a clinical predictor of outcomes in secondary perforation peritonitis.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18.00 Year(s) 至 90.00 Year(s)（—）
- 性别
- All
入选标准
- •PATIENT WILLING FOR PARTICIPATION IN THE STUDY ALL PATIENTS PRESENTING IN EMERGENCY WITH FEATURES OF SECONDARY PERFORATION PERITONITIS ON CLINICAL EXAMINATION AND RADIOLOGICAL INVESTIGATIONS.
排除标准
- •1.Patients operated outside Government Medical College and Hospital for secondary perforation peritonitis and later referred to the centre for management of complications.
- •Patients with other causes of raised neutrophil to lymphocyte ratio (NLR), which include malignancy, cardiovascular diseases, acute respiratory distress syndrome, fibrotic liver diseases, person living with HIV, patient with tuberculosis, patient on steroid therapy.
- •Patients with other causes of perforation peritonitis which includes spontaneous bacterial peritonitis and tertiary peritonitis.
结局指标
主要结局
To evaluate the relationship between NLR and mortality within hospital stay of patients with secondary perforation peritonitis
时间窗: 30 DAYS
次要结局
- 1.TO EVALUATE THE RELATIONSHIP BETWEEN NLR AND MORBIDITY(2.To evaluate the incidence of morbidity,which includes)
研究者
Asha Rani
Panjab University, Chandigarh