To compare individualized Positive End-Expiratory Pressure with Standard Positive End-Expiratory Pressure on Lung Function in patients undergoing Laparoscopic Surgery
Phase 4
- Conditions
- Health Condition 1: K801- Calculus of gallbladder with othercholecystitisHealth Condition 2: O- Medical and SurgicalHealth Condition 3: N29- Other disorders of kidney and ureter in diseases classified elsewhereHealth Condition 4: N858- Other specified noninflammatory disorders of uterus
- Registration Number
- CTRI/2021/08/035897
- Lead Sponsor
- one
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
•American Society of Anaesthesiologists (ASA) grading I and II.
•Posted electively for laparoscopic surgery
Exclusion Criteria
•Preexisting cardiorespiratory, kidney or neuromuscular disease.
•Pre-existing lung pathology.
•Obese (BMI > 30 kg/m2).
•Contraindication to PEEP initiation like increased intracranial pressure or hypotension.
•Refusal to participate in study.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To compare individualized PEEP with standard PEEP on postoperative PaO2/FiO2 ratio.Timepoint: ABG will be done preoperatively, 1 hour after pneumoperitoneum and 1 hour after extubation.
- Secondary Outcome Measures
Name Time Method 1.To compare individualized PEEP with standard PEEP on postoperative pulmonary complications (PPC) which include atelectasis, pneumonia, pneumothorax etcTimepoint: USG chest will be done preoperatively and 1 hour after extubation.;2.To compare the changes in arterial blood gas (ABG) parameters including: <br/ ><br>(a)PaCO2 <br/ ><br>(b)PaO2 <br/ ><br>(c)HCO3 <br/ ><br>(d)pH <br/ ><br>Timepoint: ABG will be done preoperatively, 1 hour after pneumoperitoneum and 1 hour after extubation.;3.To compare the changes in parameters of PFT using portable spirometry. <br/ ><br>(a)FEV1 <br/ ><br>(b)FEVI/FVC <br/ ><br>(c)PEF <br/ ><br>(d)MEF (25-75%) <br/ ><br>Timepoint: Portable spirometry will be done preoperatively, and 1 hour after extubation.