Comparison of the effect of Nerve Block with Marcaine and Normal Saline on stress response in patients undergoing general anesthesia
Not Applicable
- Conditions
- General Anesthesia.Intravenous Anesthetics, Other and Unspecified General Anesthetics, Local AnestheticsT41.1? T41
- Registration Number
- IRCT2015100824268N2
- Lead Sponsor
- Vice Chancellor For Research of University, Tehran University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 52
Inclusion Criteria
Age 18-60 years, BMI<30, Stage 1 and 2 ASA, Surgery time less than 2 hours; Absence of systemic disease such as (heart or lung disease and serious liver-Kidney disease); Absence of contraindications to epidural anesthesia (coagulopathies, infection at needle insertion site, the patient's lack of cooperation, absence consent); Absence of any contraindications to perform Block; Absence of a history of immunosuppressive and corticosteroid drugs; Absence of a history of drug addiction and smoking. Exclusion criteria: Failing to block, Incidence of complications during surgery and laparotomy for any reason, Prolongation of operation (more than 2 hours)
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Pain. Timepoint: Immediately, 6, 12, 24 hours after discharge from recovery. Method of measurement: Visualized Analogue Scale.;The Subjective Success Rate of Block. Timepoint: 30 minute. Method of measurement: Check the skin sensation of the same area of block in the epigastric and umbilical and groin.;Objective success rate of blockage for anesthesia by injection and deposition of the sediment material (Marcaine) between the layers of muscle (IOM and TAM). Timepoint: During of surgery. Method of measurement: Ultrasound sonography.
- Secondary Outcome Measures
Name Time Method Blood Sugar ,WBC , CRP , Cortisol, TNF-a and IL-1 level of serum. Timepoint: Before induction of anesthesia and 6 and 24 hours after extubation of patient. Method of measurement: Blood Exam.