NCT00354991已完成3 期
An Open Label Study to Assess the Efficacy of Losartan/HCTZ Combination Therapy in Patients With Essential Hypertension Who Were Inadequately Controlled on Current Antihypertensive Monotherapy
适应症
干预措施
相关药物
试验速览
- 阶段
- 3 期
- 状态
- 已完成
- 入组人数
- 437
- 主要终点
- Percentage of patients reaching a blood pressure goal (diastolic <90mm Hg for non-diabetics; <80mm Hg for diabetics) after 8 weeks of treatment
研究概览
简要总结
The objective of the study is to estimate the percentage of patients who reach blood pressure goal after 8 weeks of treatment with losartan/HCTZ combination.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patient is male or female and = 18 years of age
- •Patients with essential hypertension previously treated with antihypertensive medications for at least 4 weeks but did not reach the blood pressure goal
排除标准
- •History of any condition, therapy, lab abnormality or other circumstance that might confound the results of the study, or interfere with the patient's participation for the full duration of the study, such that it is not in the best interest of the patient/subject to participate
- •Pregnant or breastfeeding, or expecting to conceive within the projected duration of the study
- •Previous history of severe essential hypertension
- •History of stroke or myocardial infarction (heart attack)
- •Evidence of renal or liver disease
- •Uncontrolled diabetes mellitus
- •Any known bleeding disorder
- •Known sensitivity or intolerance to the study medication (losartan or hydrochlorothiazide)
- •Other antihypertensive medications or medications that may affect blood pressure
研究组 & 干预措施
1
Experimental
Losartan/HCTZ
干预措施: losartan potassium (+) hydrochlorothiazide (Drug)
结局指标
主要结局
Percentage of patients reaching a blood pressure goal (diastolic <90mm Hg for non-diabetics; <80mm Hg for diabetics) after 8 weeks of treatment
时间窗: 8 Weeks
次要结局
- Safety and tolerability(13 Weeks)
研究者
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