Effect of Inspiratory Muscle Training and Early Mobilization Program on Weaning of Mechanical Ventilation in Critically Ill Patients

Phase 2

• Conditions: Patients who failed simple weaning from mechanical ventilation.; Inspiratory muscle training; Body composition; Physical therapy; Early mobilization; Intensive care; Weaning failure

• Registration Number: TCTR20181220005
• Lead Sponsor: Faculty of Associated Medical Sciences, Chiang Mai University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2018-12-20
• Study Completion: 2021-01-01
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Pending (Not yet recruiting)
• Sex: All
• Target Recruitment: 110

Inclusion Criteria

1. Participants aged 18 years old or more who will have to undergo mechanical ventilation via endotracheal tube and failed simple weaning.
2. Good consciousness and cooperation
3. Hemodynamic stable (no hypotension, SBP between 90-170 mmHg, MAP not varying by > 10 mmHg, Oxygen saturation > 92%, no need vasopressor or use very low levels)
4. Respiratory stable (FiO2 < 0.60, no use respiratory-depressant drugs)
5. No active sepsis
6. No hyperthermia
7. Underlying disease stable and causes for respiratory failure are resolved
8. Psychologically stable

Exclusion Criteria

1. Insufficient chronic congestive heart failure, life-threatening cardiac arrhythmias, cardiovascular instability
2. End stage of lung cancer
3. Neurological disease (cerebral vascular accident, cerebrospinal trauma, spinal medullar trauma, myopathy)
4. Severe orthopedic problems, musculoskeletal pathology that impact chest movement
5. Endocrine system and metabolic system dysfunction (hypothyroidism, malnutrition)
6. Obesity (BMI ≥ 40 kg/m2)
7. Pregnancy
8. Significantly pain or distress experience that impeded in breathing capacity
9. Use attention disorder drugs and/or sedative agents
10. Palliation
11. Pre-ICU admission status; inability to walk without assistance (except using cane or walkers)
12 Cardiopulmonary resuscitation (CPR) at admission, do not resuscitate at admission
13. Readmission to ICU within current hospitalization

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Mechanical ventilation duration 48 hours after extubation Days/duration of mechanical ventilation will be recorded from the date of failed simple weaning to e

Secondary Outcome Measures

Name	Time	Method
Maximal inspiratory pressure (MIP) Prior to treatment and 48 hours after extubation cmH2O/Forceful inspiratary pressure will be measured by using the POWERbreathe KH2 device. ,Limbs muscle force Prior to treatment and 48 hours after extubation kg/Limbs muscle forces will be measured by using a hand-held dynamometer (Lafayette).,Body composition Prior to treatment and 48 hours after extubation kg/Body composition will be measured by using InBodyS10.