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临床试验/CTRI/2025/06/088917
CTRI/2025/06/088917招募中不适用

A Prospective Randomised study to compare the efficacy of volume controlled ventilation and pressure support ventilation in patients undergoing coronary artery bypass grafting off pump surgeries.

Kiranmuthrajah1 个研究点 分布在 1 个国家目标入组 100 人开始时间: 2025年6月28日最近更新:

试验速览

阶段
不适用
状态
招募中
发起方
入组人数
100
试验地点
1
主要终点
Development of post-operative pulmonary complications:

研究概览

简要总结

This comparative study aimed to evaluate the efficacy of volume controlled ventilation versus pressure controlled ventilation modes during surgery in preventing postoperative pulmonary complications in patients undergoing coronary artery bypass grafting. patients scheduled for elective CABG were randomly assigned to receive either VCV or PVC intraoperatively. The objective of the study was to assess the incidence of post operative pulmonary complications such as atelectasis, pneumonia, hypoxaemia and prolonged ventilation in postoperative period. The study aimed to identify the ventilation strategy that offers superior pulmonary protection and better postoperative respiratory outcomes. in patients undergoing CABG.

研究设计

研究类型
Interventional
分配方式
Randomized
盲法
Participant and Outcome Assessor Blinded

入排标准

年龄范围
18.00 Year(s) 至 90.00 Year(s)(—)
性别
All

入选标准

  • 18 years of age or older
  • Scheduled for elective cardiac surgery with general anesthesia, invasive mechanical ventilation, complete median sternotomy.

排除标准

  • Patients were excluded in case of emergent or redo surgeries
  • Patients with history of COPD.
  • Patients with known pulmonary Hypertension
  • Patients with EF less than 40% in Echocardiography
  • Patients with significant history of smoking addiction
  • Body mass index more than 35 kg/ m2
  • Obstructive sleep apnea
  • Patient Refusal.

结局指标

主要结局

Development of post-operative pulmonary complications:

时间窗: 30minutes/60minutes/2hours/4hours/8hour/16hours/24hours/48hours/72hours

(Post-extubation respiratory failure, Bronchospasm, Severe trachea–bronchial congestion,

时间窗: 30minutes/60minutes/2hours/4hours/8hour/16hours/24hours/48hours/72hours

Respiratory acidosis, Suspected or confirmed pneumonia, Pleural effusion, Radiological

时间窗: 30minutes/60minutes/2hours/4hours/8hour/16hours/24hours/48hours/72hours

atelectasis, acute respiratory distress syndrome, prolonged invasive ventilation associated

时间窗: 30minutes/60minutes/2hours/4hours/8hour/16hours/24hours/48hours/72hours

with hypoxemia)

时间窗: 30minutes/60minutes/2hours/4hours/8hour/16hours/24hours/48hours/72hours

次要结局

  • Duration of ICU stay(At baseline)

研究者

发起方
Kiranmuthrajah
申办方类型
Other [self]
责任方
Principal Investigator
主要研究者

Dr Kiran Muthu Rajah

Sri Ramachandra Institute of Higher Education and Research

研究点 (1)

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