Bayesian optimized Propofol Target-Controlled Infusio
- Conditions
- elective surgery under general anaesthesia with propofol and requiring an arterial line for invasive blood pressure monitoring as part of their clinical careTarget-Controlled Infusion,propofol,pk/pd
- Registration Number
- NL-OMON23794
- Lead Sponsor
- niversity medical center groningen, university of groningen, the netherlands
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 120
Inclusion Criteria
Age between : 18 years and 75 years
-Informed patient consent
Exclusion Criteria
•patient refusal
•CNS diseases (dementia, CVI, seizures, psychiatric diseases)
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method We hypothesize that online adaptation or individualization of the population PKPD model of propofol will decrease the residual error between predicted and measured plasma-concentrations during maintenance of anaesthesia, when the adapted PKPD models are used to calculate propofol infusion rates required for the plasma concentrations set by the responsible anaesthetist
- Secondary Outcome Measures
Name Time Method Secondly, we will compare the hypnotic and haemodynamic stability before and after the adaptation as measured by EEG and other vital signs clinical monitoring