CMR based myocardial tissue characterization in correlation with functional and flow-dynamic processes in patients with severe aortic stenosis prior to and after TAVI

Not Applicable

• Conditions: I35.0; Aortic (valve) stenosis

• Registration Number: DRKS00009370
• Lead Sponsor: niklinik KölnInstitut für Diagnostische und Interventionelle Radiologie

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2015-09-17
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Pending
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

Patients with severe aortic stenosis who will undergo a TAVI procedure.
Control group: Healthy volunteers without any known heart disease.

Exclusion Criteria

MR contraindications (pacemakers, insulin pumps, cochlea implants, etc.); severe renal insufficiency (GFR < 30 ml/min); hemodynamic significant heart insufficiency that would lead to relevant additional stress for the patient during the examination.

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
After acquisition of CMR data before and 6 months after TAVI, all data (T1, strain, flow parameters, volumetry, late enhancement) will be quantified using various software algorithms. All data of both examinations will be compared to the group of healthy volunteers.