A comparison of dexmedetomidine-thiopental with propofol for sedation in children undergoing magnetic resonance imaging (MRI)

Not Applicable

Completed

• Conditions: Patient sedationHemodynamic changes; Children; Sedation; Magnetic resonance imaging(MRI); Thiopental; Dexmedetomidine; Propofol

• Registration Number: TCTR20170707001
• Lead Sponsor: Ramathibodi Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2017-07-07
• Study Completion: 2017-08-04
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

1.The patients were 1 to 10 years old.
2.The patients were underwent MRI.
3.The patients had ASA physical status 1-3.
4.The patients did not eat at least 6 hours and they did not drink at least 2 hours before sedation.
5.The patients' parents accepted to join this study.

Exclusion Criteria

1.The patients had heart disease.
2.The patients had respiratory tract infection.
3.The patients had sepsis or shock.
4.The patients had asthma.
5.The patients had history of allergy to thiopental, dexmedetomidine,and propofol.
6.The patients used psychiatric drugs, sedative drugs, alpha-2 agonist drugs, beta blocker drugs, and digoxin.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Quality of MRI 0-60 min after sedation Score of the patient's movement during sedation,Onset of sedation time After injection Time to sleep

Secondary Outcome Measures

Name	Time	Method
Presedation behavior Before sedation Score of presedation behavior,Ramsay sedation score 0-60 min after sedation Score of sedation,Blood pressure 0-60 min after sedation Systolic and diatolic blood pressure (mmHg),Heart rate 0-60 min after sedation Heart rate (beats per min),Respiratory rate 0-60 min after sedation Respiratory rate (times per min),End-tidal CO2 0-60 min after sedation Carbondioxide in expiration (mmHg),Oxygen saturation 0-60 min after sedation Pulse oximetry (%),Recovery time After discontinue medication Time to wake up (Ramsay score 2),Discharge time After discontinue medication Time to discharge from recovery room,Adverse events After injection until discharge from recovery room Record of adverse event