An RCT of Metoclopramide/Diphenhydramine vs. Ketorolac Alone for Tension-type Headache
Overview
- Phase
- Phase 4
- Intervention
- Ketorolac
- Conditions
- Headache
- Sponsor
- Montefiore Medical Center
- Enrollment
- 123
- Locations
- 1
- Primary Endpoint
- Change in Pain Score
- Status
- Completed
- Last Updated
- 7 years ago
Overview
Brief Summary
Occasionally, episodic tension-type headache may be severe enough to require an emergency department (ED) visit. The purpose of this study is to compare two commonly used medications to see which is better for tension type headache. Patients who present to the ED with an acute tension-type headache requiring treatment with injectable medication will be randomized to metoclopramide or ketorolac.
Investigators
Benjamin W. Friedman, MD
Associate professor
Montefiore Medical Center
Eligibility Criteria
Inclusion Criteria
- •Acute tension type headache
Exclusion Criteria
- •Contraindications to investigational medications
- •Secondary cause of headache
Arms & Interventions
Ketorolac
Ketorolac 30mg IVSS
Intervention: Ketorolac
Metoclopramide
metoclopramide 20mg IVSS + diphenhydramine 25mg IVSS
Intervention: Metoclopramide
Outcomes
Primary Outcomes
Change in Pain Score
Time Frame: Baseline, 60 minutes
At baseline at at 60 minutes, all patients were asked to describe their pain on a scale from 0 to 10, with 0 representing no pain and 10 the worst imaginable. The primary outcome is the 60 minute score subtracted from the baseline score
Secondary Outcomes
- Satisfaction Scores(24 hours)