Episodic Memory Before and After Surgery in Drug-resistant Partial Epilepsies

Not Applicable

• Conditions: Memory Impairment; Epilepsy, Unspecified, Pharmacologically Resistant
• Interventions: Other: No intervention

• Registration Number: NCT01919957
• Lead Sponsor: Institut National de la Santé Et de la Recherche Médicale, France

Brief Summary

This study has two purposes: firstly, a better understanding of the neurobiological processes underlying episodic memory and, secondly, the development of useful clinical applications for epileptic patients, in particular the prediction of postoperative memory deficits and the development of cognitive remediation therapies.

Memory performances during a fMRI experiment will be assessed in controls and epileptic patients before and after the surgery.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2013-07-01
• Study First Submitted QC: 2013-08-07
• Study First Posted: 2013-08-09
• Study Start: 2013-10
• Status Verified: 2015-02
• Last Update Submitted: 2015-02-05
• Last Update Posted: 2015-02-06
• Primary Completion: 2021-12
• Study Completion: 2022-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 120

Inclusion Criteria

• Patients with drug-resistant epilepsy
• Age of 18 years or more
• Follow-up in the epilepsy unit at Pitié-Salpêtrière Hospital
• Before or after the presurgical evaluation unit including a video-EEG monitoring, a structural brain imaging and a full neuropsychological assessment
• Covered by a social security system
• Signing of consent form

Exclusion Criteria

• Persons under guardianship, curatorship or any other administrative or judicial deprivation of rights and freedom
• Refusal to consent form
• Contraindications to MRI
• Pregnancy
• Refusal to be informed in the case of detection of an abnormality during the experiment

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
memory outcome	No intervention	-

Primary Outcome Measures

Name	Time	Method
Measure of successfull encoding	8 years	Our goal is to define correlation between the measure of successfull object encoding trials (especially for binding) and the beta value activation in fMRI

Trial Locations

Locations (1)

INSERM - Plateau IRM du CENIR, CR-ICM Hôpital Pitié-Salpêtrière, 47/83 Boulevard de l'Hôpital; 🇫🇷 Paris, Cedex 13, France