Image validation of laryngeal and hypopharyngeal cancer with histopathology for radiotherapy.
Completed
- Conditions
- larygeal cancerlarynx carcinoma10027655
- Registration Number
- NL-OMON33702
- Lead Sponsor
- niversitair Medisch Centrum Utrecht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 28
Inclusion Criteria
Patients of the above population scheduled for total laryngectomy.
Informed consent
Exclusion Criteria
Patients with indications for primary radiotherapy.
Patients with contraindications for surgery.
Patients who meet exclusion criteria for MRI at 1.5 T as defined in the protocols of the radiology department.
Patients with contraindication for CT contrast administration as defined in the protocols of the radiology department.
Patients with insulin dependent diabetes mellitus.
no informed consent.
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The accuracy of the different image modalities to measure the tumour volume and<br /><br>outline as determined by comparison with histopathology as reference standard. </p><br>
- Secondary Outcome Measures
Name Time Method <p>· assessment of microscopic invasion of the tumour in the surrounding tissue by<br /><br>histopathology.<br /><br><br /><br>· determination of the interobserver variation for tumour delineation using the<br /><br>different image modalities.<br /><br><br /><br>· feasibility of diffusion weighted imaging for laryngeal and hypopharyngeal<br /><br>cancer.<br /><br><br /><br>· development of a clinical imaging protocol for gross tumour volume (GTV) and<br /><br>clinical tumour volume (CTV) delineation.</p><br>