Brown Fat Activity and White Fat Accumulation

Completed

• Conditions: Hodgkins Lymphoma; Non-hodgkins Lymphoma

• Registration Number: NCT01517581
• Lead Sponsor: Children's Hospital Los Angeles

Brief Summary

White and brown adipocytes differ in their expression of hormones, cytokines, and inflammatory factors, and they modulate different biological functions. While white adipose tissue (WAT) serves as the primary site of energy storage, brown adipose tissue (BAT) instead metabolizes fat to produce heat and regulate body temperature. BAT is likely present in all humans, but the low prevalence of BAT depiction in adults and elderly subjects has hindered longitudinal assessments of the relation between BAT activity and WAT. Under typical imaging conditions, BAT is detected more frequently in children and teenagers than in adults with malignancy. Since most children with cancer have significantly shorter treatment courses and greater survival rates compared to adult patients, the investigators have the ability to examine the relation of repeated measures of body composition and BAT by selecting pediatric patients. In this study, the investigators will longitudinally examine whether BAT activity is related to changes in weight and the amounts of SAT, VAT, and abdominal muscle in children successfully treated for pediatric cancer.

Detailed Description

Not available

Study Timeline

• Study Start: 2008-10
• Primary Completion: 2011-09
• Study Completion: 2011-09
• Status Verified: 2012-01
• Study First Submitted: 2012-01-20
• Study First Submitted QC: 2012-01-24
• Last Update Submitted: 2012-01-24
• Study First Posted: 2012-01-25
• Last Update Posted: 2012-01-25

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 32

Inclusion Criteria

• Patients had PET/CT scans with evidence of malignant disease
• Patients had no metabolically active BAT at diagnosis on their PET/CT scan
• Patients were disease free within 1 year of diagnosis

Exclusion Criteria

• Patients had PET/CT scans with no evidence of malignant disease
• Patients with metabolically active BAT at diagnosis on their PET/CT scan
• Patients were not disease free within 1 year of diagnosis

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Change from Baseline in Subcutaneous Adipose Tissue Volume at Follow-up	Baseline and up to 1 year
Change from Baseline in Visceral Adipose Tissue Volume at Follow-up	Baseline and up to 1 year
Change from Baseline in Presence of Brown Adipose Tissue	Baseline and up to 1 year
Change from Baseline in Abdominal Musculature Volume	Baseline and up to 1 year

Secondary Outcome Measures

Name	Time	Method
Change from Baseline in Anthropometric Measures at Follow-up	Baseline and up to 1 year	Age, height, weight and BMI

Trial Locations

Locations (1)

Children's Hospital Los Angeles; 🇺🇸 Los Angeles, California, United States