Brown Adipose Tissue Activity in Caucasians and South Asians
- Conditions
- metabolism10018424Diabetes
- Registration Number
- NL-OMON36373
- Lead Sponsor
- Academisch Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 20
Inclusion Criteria
Male
European or South Asian origin
Subjects should be able and willing to give informed consent
18-35 years old
BMI range of 20-25 kg/m2
Exclusion Criteria
Renal failure (kreatinine>135mmol/l)
Use of prescription medication
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Difference in Standardised Uptake Value (SUV) of the tracer<br /><br>18F-fluorodeoxyglucose (FDG) visualised with PET-CT in BAT (Caucasians vs South<br /><br>Asians)</p><br>
- Secondary Outcome Measures
Name Time Method <p>-Difference in SUV of the tracer I-123 metaiodobenzylguanidine (MIBG) in BAT<br /><br>(Caucasians vs South Asians)<br /><br>-Correlation between SUV of the tracer MIBG and SUV of the tracer FDG (both in<br /><br>the total group and Caucasians vs South Asians)<br /><br>-Correlation between insulin sensitivity (as measured by euglycemic insulin<br /><br>clamp) and SUV of the tracer FDG.</p><br>