Activation of brown adipose tissue in lean and obese me

Completed

• Conditions: overgewicht; morbidly overweight; Obesity; 10018424

• Registration Number: NL-OMON39965
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 23

Inclusion Criteria

- Male
- Caucasian origin
- Subjects should be able and willing to give informed consent
- 18-40 years old
- BMI range of 19-25 kg/m2 (lean study subjects) or 28-40 kg/m2 (obese study subjects)

Exclusion Criteria

- Renal failure (creatinine>135mmol/l)
- Daily use of prescription medication
- Prior participation in a research protocol involving radiation exposure in the last 2 years

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Difference in semi-quantitative uptake of the tracer MIBG visualised with<br /><br>SPECT-CT in BAT (lean vs obese individuals)</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Difference in correlation between semi-quantitative uptake of MIBG and standard<br /><br>uptake value of FDG (lean vs obese individuals)<br /><br><br /><br>Correlation between the difference in resting energy expenditure during<br /><br>thermoneutral conditions and during mild cold exposure and semi-quantitative<br /><br>uptake of MIBG, or standard uptake value of FDG </p><br>