Brown Adipose Tissue in Type 1 Diabetes

Not Applicable

Completed

• Conditions: Type1diabetes
• Interventions: Radiation: Positron emission tomography with tracer 18F-deoxy glucose

• Registration Number: NCT02984514
• Lead Sponsor: Per-Ola Carlsson

Brief Summary

Brown adipose tissue has the capacity to consume large amounts of energy and has insulin-independent glucose uptake. The investigators have recently observed an inverse correlation between irisin levels and insulin needs of type 1 diabetes patients. Transplantation of brown adipose tissue to insulin-deficient rats normalized their blood glucose levels.

In this study 12 patients with long-standing type 1 diabetes (\>10 years) and with variable exogenous insulin needs will be investigated for amount of brown adipose tissue with positron emission tomography using the tracer 18F-deoxy glucose.

Detailed Description

Not available

Study Timeline

• Study Start: 2015-10
• Study First Submitted: 2016-11-30
• Study First Submitted QC: 2016-12-02
• Study First Posted: 2016-12-07
• Primary Completion: 2018-01
• Study Completion: 2018-06
• Status Verified: 2018-10
• Last Update Submitted: 2018-10-10
• Last Update Posted: 2018-10-11

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 11

Inclusion Criteria

1. Adult patients (18 years of age or more)
2. Type 1 diabetes diagnose for more than 10 years

Exclusion Criteria

1. Ongoing pregnancy
2. Ongoing breast-feeding
3. BMI<19
4. BMI >30
5. P-creatinine <110 µmol/l

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Type 1 diabetes	Positron emission tomography with tracer 18F-deoxy glucose	Positron emission tomography with tracer 18F-deoxy glucose

Primary Outcome Measures

Name	Time	Method
Activity of brown adipose tissue in correlation to exogenous insulin needs using the tracer 18F-deoxy glucose in positron emission tomography measurements	Assessment performed after more than 10 years of diagnosed type 1 diabetes

Secondary Outcome Measures

Name	Time	Method
Glucose uptake in muscle in correlation to exogenous insulin needs; assessment using the tracer 18F deoxy glucose in positron emission tomography measurements.	Assessment performed after more than 10 years of diagnosed type 1 diabetes

Trial Locations

Locations (1)

Uppsala University Hospital; 🇸🇪 Uppsala, Sweden