Activity of Brown Adipose Tissue during hypoglycaEmia
- Conditions
- diabetesmetabolism1001265310018424
- Registration Number
- NL-OMON36610
- Lead Sponsor
- Academisch Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 16
Inclusion criteria for healthy volunteers
* Male
* Caucasian race
* 18-50 years old
* BMI 20-28 kg/ m2
* Subjects should be able and willing to give informed consent;Inclusion criteria for type 1 diabetes patients
* Male
* Caucasian race
* Age 18-50 years
* BMI 20-28 kg/ m2
* Type 1 Diabetes Mellitus
* Subjects should be able and willing to give informed consent
Exclusion criteria for healthy volunteers
* Use of prescription medications (beta-adrenoreceptor blockers)
* Cardiac history (previous arrhythmia)
* History of epilepsy
* Acute illness within 3 months before the study
* Significant renal impairment (creatinine clearance <50ml/min)
* Family history of diabetes;Exclusion criteria for type 1 diabetes patients
* Impaired awareness of hypoglycaemia
* Evidence of severe diabetes complications (autonomic neuropathy, macroalbuminuria, proliferative retinopathy)
* Use of beta-adrenoreceptor blockers
* Cardiac history (previous arrhythmia)
* History of epilepsy
* Acute illness within 3 months before the study
* Significant renal impairment (creatinine clearance <50ml/min)
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Change in Standardised Uptake Value (SUV) of the tracer<br /><br>[18F]-fluorodeoxyglucose (FDG) visualised with positron emission tomography<br /><br>(PET) in BAT (normoglycaemia vs. hypoglycaemia).</p><br>
- Secondary Outcome Measures
Name Time Method <p>Difference between the change in SUV in BAT in the group with healthy<br /><br>volunteers versus the diabetes patients. </p><br>