Role of brown adipose tissue in meal-induced thermogenesis and the involvement of the sympathetic nervous system

Recruiting

• Conditions: Obesitas; nvt

• Registration Number: NL-OMON38243
• Lead Sponsor: niversiteit Maastricht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 34

Inclusion Criteria

• Healthy lean and obese adults
• Age 18-30 years
• Gender: Male
• Lean: BMI 18.5-25 kg/m2;Obese: BMI >= 30 kg/m2
• Caucasians

Exclusion Criteria

• Diabetes Mellitus
• Hyperthyroidism
• Cardiovascular and renal diseases
• Tachy-arrhythmias
• Asthma and other obstructive pulmonary diseases
• Hypertension (systolic/diastolic blood pressure >140/90)
• Hypotension (systolic/diastolic blood pressure <90/60)
• Elevated fasting blood glucose level (> 5.6 mmol/L)
• Medication: use of ß-blockers, tricylic antidepressants, MAO inhibitors
• Glaucoom: use of the medicine betamimeticum
• Individuen die al eerder mee hebben gedaan aan bruin vet onderzoek met een PET-CT scan
of al een keer medische bestraling hebben gehad
• Jicht
• Lever insufficiëntie

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>- Standard uptake value*s (SUV*s) of brown adipose tissue<br /><br>- Skeletal muscle mitochondrial respiration/uncoupling<br /><br>- Energy expenditure</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>- Body temperatures<br /><br>- Skin perfusion<br /><br>- Body composition<br /><br>- Blood parameters<br /><br>- UCP-1 and beta3-receptor polymorphisms</p><br>