Activation of Brown Adipose Tissue in Old and Young Individuals

Completed

Conditions: Obesity
Overweight and age
10018424
10001474

Registration Number: NL-OMON39994

Lead Sponsor: Academisch Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 24

Inclusion Criteria

Male
Caucasian Origin
18-65 years old
BMI range 19-27kg/m2
Subjects should be able and willing to give informed consent

Exclusion Criteria

Renal failure (creatinine >135 mmol/L)
Daily use of prescription medicine
Prior participation in a research protocol involving radiation exposure in the last 2 years

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Difference in semi quantitative uptake value of the tracer MIBG visualised with<br /><br>SPECT-CT in BAT (younger versus older individuals).</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>The correlation between semi-quantitative uptake of MIBG and SUV of FDG in<br /><br>young and older individuals will be calculated with a Pearson correlation<br /><br>coefficient.<br /><br>P-values for the difference in resting energy expenditure during thermoneutral<br /><br>conditions and during mild cold-exposure will be calculated with independent<br /><br>sample t-tests. Subsequently, the correlation between this difference in<br /><br>resting energy expenditure and the sympathetic stimulation of BAT as assessed<br /><br>with MIBG (and with metabolic BAT activity as assessed with FDG), will be<br /><br>calculated with a Pearson correlation coefficient.<br /><br>The correlation between insulin resistance in different age groups, and<br /><br>semi-quantitative uptake of MIBG, or SUV of FDG will be calculated with a<br /><br>Pearson correlation coefficient<br /><br>In view of the limited size of the study, no multivariate analyses will be<br /><br>performed. </p><br>