Human Brown Adipose Tissue Histological and Mitochondrial Respiratory Analysis

Recruiting

• Conditions: obesitas; obesity; 10003018

• Registration Number: NL-OMON47232
• Lead Sponsor: niversiteit Maastricht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 180

Inclusion Criteria

Patients indicated for surgery in the supraclavicular and neck region are included. More specific, patients diagnosed with hyperparathyroidea, struma, benign thyroid gland tumours, implantation of a vagal neurostimulator for epilepsia and cervical neurologic disorders, aged 18-65 years will be included.

Exclusion Criteria

Only patients indicated for elective surgery will be included. Patients undergoing acute surgery because of critical illness are excluded. In this patient group informed consent is difficult to obtain and severe inflammation could influence BAT-, WAT- and skeletal muscle responses. Patients with pre-operative mailgn tumours will be excluded.

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The primary endpoint will be the quantification of mitochondrial respiration in<br /><br>human BAT. Secondary endpoints will be histological protein stainings and<br /><br>mitochondrial content analysis of human BAT. An UCP-1 immunofluorescence assay<br /><br>will be used to detect UCP-1.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>none</p><br>