Will folic acid supplements taken throughout pregnancy reduce the incidence of recurrent pre-eclampsia in women with high blood homocysteine concentrations?

Phase 3

• Conditions: hyperhomocysteinaemia.; pre-eclampsia; Metabolic and Endocrine - Other metabolic disorders; Reproductive Health and Childbirth - Antenatal care; Cardiovascular - Other cardiovascular diseases

• Registration Number: ACTRN12614001241628
• Lead Sponsor: Women's and Children's Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2014-11-26
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Stopped early
• Sex: Female
• Target Recruitment: 626

Inclusion Criteria

Singleton pregnancy between > or = 12 and < or = 20 weeks gestation; past history of severe pre-eclampsia; hyperhomocysteinaemia (>11 umol in pregnancy, >13 outside pregnancy).

Exclusion Criteria

No known vitamin B12 deficiency; no epilepsy taking anticonvulsants; no known homocystinuria; no multiple pregnancy; no medical need for folate supplementation.

Study & Design

• Study Type: Interventional
• Study Design: Not specified