The effect of increasing pulmonary ventilation in methanol poisoning

Phase 2

• Conditions: Toxic alcohols.; Toxic effect of methanol; T51.1

• Registration Number: IRCT20120629010133N5
• Lead Sponsor: Shahid Beheshti University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 22 January 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

Adult patients, men & women diagnosed with methanol poisoning
Serum methanol = 50mg/dL
pH = 7.0, correctable by bicarbonate infusion
no visual disturbances

Exclusion Criteria

Acidosis requiring haemodialysis
Comatose patients

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Change in methanol elimination kinetics (half-life and estimated clearance) when iHV is utilized. Timepoint: Hourly before intervention, and 1-2 hourly post intervention till 24 hours. Method of measurement: Measuring serum/urine methanol, formate.

Secondary Outcome Measures

Name	Time	Method
Score of iHV machine tolerability. Timepoint: Hourly. Method of measurement: Qualitative interview.;Score of feasibility of iHV machine. Timepoint: Hourly. Method of measurement: Likert's scale.;Implementation of fomepizole in Iran. Timepoint: End of trial. Method of measurement: Likert's scale.;Length of ICU- and hospital stay during treatment with iHV. Timepoint: End of trial. Method of measurement: Time frame of hospital stay.;Death. Timepoint: End of trial. Method of measurement: Yes or No.;Need for haemodialysis. Timepoint: hourly. Method of measurement: Yes or No.;Adverse Events. Timepoint: hourly. Method of measurement: Yes or No.