Effect of Weight Loss and Physical Training on Musculoskeletal Status, Physical Function, and Quality-of-Life in Physically Limited, Obese, Elderly Subjects

Washington University School of Medicine1 site in 1 country28 target enrollmentJanuary 2003

ConditionsObesity Frailty Elderly

Overview

Phase: Phase 3
Intervention: Not specified
Conditions: Obesity
Sponsor: Washington University School of Medicine
Enrollment: 28
Locations: 1
Primary Endpoint: physical function and body composition
Status: Completed
Last Updated: 20 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

The overall purpose of this research is to determine the effect of weight loss and physical training on quality of life, physical function, metabolism, bone strength, body fat and muscle mass.

Detailed Description

Obesity causes serious medical complications and impairs quality of life. Moreover, in elderly persons, obesity can lead to frailty because of decreased strength, joint function, balance and mobility associated with aging. The primary objective of this study is to evaluate the effect of weight loss and physical training on physical function, body composition, metabolism and quality of life in frail, obese elderly men and women. Subjects are randomized to either control or 10% weight loss plus physical training.

Registry

clinicaltrials.gov

Start Date

January 2003

End Date

December 2004

Last Updated

20 years ago

Study Type

Interventional

Study Design

Parallel

Sex

All

Investigators

Sponsor

Washington University School of Medicine

Eligibility Criteria

Inclusion Criteria

•Obese (BMI 30 or greater) elderly (age 65 years or older) Frailty

Exclusion Criteria

•Major chronic disease or any condition that would interfere with exercise or dietary restriction, in which exercise or dietary restriction are contraindicated, or that would interfere with interpretation of results. Examples include cardiopulmonary disease, unstable disease, severe orthopedic or neuromuscular impairments, dementia, history of malignancy during the past 5 yr, current use of bone acting drugs.