Physical Activity is Healthy - Effect of Weight Loss or Physical Training Per se?

University of Copenhagen1 site in 1 country60 target enrollmentMarch 2007

ConditionsInsulin Sensitivity

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Insulin Sensitivity
Sponsor: University of Copenhagen
Enrollment: 60
Locations: 1
Primary Endpoint: Change in insulin sensitivity
Status: Completed
Last Updated: 16 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

The investigators aimed to evaluate the health benefits of physical training per se, weight loss per se and exercise-induced weight loss in young, overweight men. The investigators hypothesized that physical training would have independent effects on various health parameters (insulin sensitivity, fasting glucose and insulin, total and abdominal fat mass, waist circumference, blood pressure and key muscle proteins), and that a concomitant weight loss from physical activity would increase the effect.

Detailed Description

At baseline, during the intervention and in the week following the intervention participants underwent a panel of tests: * Cardio respiratory fitness * blood pressure * anthropometric measures At baseline and after the intervention a hyperinsulinemic, euglycemic clamp were performed to asses insulin sensitivity. Tissue and blood samples were also collected for further analysis: * Total-protein analysis of selected proteins * Fasting plasma glucose, insulin and free fatty acids

Registry

clinicaltrials.gov

Start Date

March 2007

End Date

June 2009

Last Updated

16 years ago

Study Type

Interventional

Study Design

Parallel

Sex

Male

Investigators

Sponsor

University of Copenhagen

Eligibility Criteria

Inclusion Criteria

•Overweight (body mass index 25-30 kg/m2)
•Weight stable (±2 kg during the past 6 months)
•Body fat% \>25%,
•Maximal oxygen uptake \<45 mL/min/kg
•Sedentary and healthy according to interview
•Fasting glucose \<6.1 mmol/L
•Blood pressure \<140/90 mmHg
•No first degree relatives with type-2-diabetes

Exclusion Criteria

•Resistance training
•Inability to meet intervention criteria

Outcomes

Primary Outcomes

Change in insulin sensitivity

Time Frame: week 0 and 13

Before and after the 12 week interventions a 1-step, 120 min, hyperinsulinaemic, euglycemic clamp was performed. After an initial 2mL bolus of insulin infusate, insulin was infused at 40 microU/min/kg.