Muscle Sympathetic Nerve Activity and Cardiovascular Organ Damage in Patients with Chronic Kidney Disease and Hypertensio

Completed

• Conditions: Hypertensie; Chronic kidney disease; Chronic Renal Disease; 10029149

• Registration Number: NL-OMON31233
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 13 May 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 60

Inclusion Criteria

Patients with hypertension (i.e. using antihypertensive drugs and/or blood pressure >145/90mmHg when off medication) with stable chronic kidney disease

Exclusion Criteria

Patients with clinically manifested cadiac history

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>-Primary endpoint: Left ventricular (LV) mass;<br /><br><br /><br>-Primary expected outcome: a proportional relation between MSNA and LV mass</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>-Secondary endpoints:<br /><br><br /><br><br /><br>o Glomerular filtration rate (GFR);<br /><br>o Ejection Fraction<br /><br><br /><br>-Secondary expected outcome:<br /><br>o Decrease in GFR as compared to baseline<br /><br>o Decrease in Ejection Fraction as compared to normal population</p><br>