Cardiac sympathetic innervation and coronary blood flow regulation during general anesthesia

Completed

• Conditions: anesthesie; 10012653; autoregulation disturbances; Diabetic neuropathy

• Registration Number: NL-OMON35529
• Lead Sponsor: Vrije Universiteit Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 65

Inclusion Criteria

Age between 18*75 years
Scheduled for non-cardiac intermediate or high risk surgery
Informed consent
For patient group 2a: indication for thoracic epidural anesthesia
For patient group 2b: undergoing robot assisted thoracic sympathectomy

Exclusion Criteria

Known/documented cardiac disease
(Untreated) hypertension
Abnormal ECG or echocardiogram
Peripheral vascular disease
Renal disease requiring hemo- or peritoneal dialysis
Inability to perform transthoracic echocardiography
Medication interfering with presynaptic catecholamine uptake
For patient group 2: contra-indication for thoracic epidural anesthesia (bleeding diasthesis, infection at the puncture site, patient refusal, severe stenotic valvular disease)
Previous allergic reaction to echocardiographic contrast agents
Contraindication for use of echocardiographic contrast agent
Pregnancy
Intracranial neurosurgery
Sympathectomy
Vascular surgery including carotidsurgery

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Changes in coronary blood flow in the absence or presence of sympathetic<br /><br>stimulation during sevoflurane anesthesia in patients with and without<br /><br>cardiovascular sympathetic innervation.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Clinical signs of cardiovascular autonomic neuropathy with cardiovascular<br /><br>reflex tests and heart rate variability. </p><br>