Scheduled Autologous PRP Guided Injection in the Maxillary Bony Defects
- Conditions
- Bony Defect
- Interventions
- Registration Number
- NCT07108933
- Lead Sponsor
- Horus University
- Brief Summary
Scheduled autologous platelet-rich plasma guided injection is done in critical-sized maxillary bony defects after surgical excision of non- malignant lesions.
- Detailed Description
The study aims to detect the effect of scheduled autologous platelet-rich plasma- guided injection in the healing process of critical-sized maxillary bony defects after surgical removal of non-malignant lesions by using bone volumetric analysis and density measuring with cone beam computed tomography.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 16
- Age: 18-65 years (adults within a specific age range).
Diagnosis: Non-malignant maxillary bony defects (e.g., benign tumors or cysts).
Health: Generally healthy participants who can tolerate surgery.
Platelet Function: No platelet disorders or blood-related conditions.
Willingness: Informed consent and ability to follow the protocol.
No Use of Blood Thinners: No current use of anticoagulants like aspirin.
- Age: Children (under 18) and elderly (over 75).
Malignant Lesions: Participants with cancer or pre-cancerous conditions.
Systemic Illness: Severe conditions (e.g., uncontrolled diabetes, autoimmune disorders).
Platelet Disorders: Low platelet count or bleeding disorders (e.g., hemophilia).
Infections: Active infections or inflammatory conditions (e.g., periodontal disease).
Pregnancy: Women who are pregnant or breastfeeding.
Recent Surgery/Trauma: Recent maxillary surgery or trauma.
Uncontrolled Medications: Use of blood thinners, NSAIDs, or immunosuppressive drugs.
Non-compliance: Unwillingness or inability to follow-up with the protocol.
Substance Abuse: Active drug or alcohol abuse.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Injection Autologous platelet-rich plasma Scheduled injection of autologous platelet-rich plasma
- Primary Outcome Measures
Name Time Method Volume of the injected bony defect after 3 months the volume of the injected bony defect is measured by Cone beam computed tomography in millimeters cubic.
- Secondary Outcome Measures
Name Time Method Bone density at the injected site after 3 months the density of bone formed at the injected site is measured by Cone beam computed tomography in Hounsfield unit.
Trial Locations
- Locations (1)
Dental clinics of Aswan University Hospital
🇪🇬Aswan, Egypt
Dental clinics of Aswan University Hospital🇪🇬Aswan, Egypt