Expanded Access to Entrectinib for Cancers With NTRK1/2/3, ROS1, or ALK Gene Fusions
- Conditions
- Cancers With NTRK, ROS1, or ALK Gene Fusions
- Registration Number
- NCT03066661
- Lead Sponsor
- Hoffmann-La Roche
- Brief Summary
Expanded access to entrectinib will be given to patients with cancers harboring NTRK1/2/3, ROS1, or ALK gene fusions who do not qualify for participation in, or who are otherwise unable to access, an ongoing clinical trial for entrectinib.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- NO_LONGER_AVAILABLE
- Sex
- All
- Target Recruitment
- Not specified
Inclusion Criteria
- Diagnosis of advanced cancer with an NTRK1, NTRK2, NTRK3, ROS1, or ALK gene fusion
- Unable to participate in an ongoing entrectinib (RXDX-101) clinical trial
- Willing and able to provide written, signed informed consent
- Medically suitable for treatment with entrectinib (RXDX-101)
Exclusion Criteria
- Currently enrolled in an ongoing clinical study with any other investigational agent
Study & Design
- Study Type
- EXPANDED_ACCESS
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular pathways does Entrectinib target in NTRK/ROS1/ALK fusion-positive cancers?
How does Entrectinib's efficacy compare to standard-of-care therapies for TRK/ROS1/ALK fusion-driven malignancies?
Which biomarkers correlate with response to Entrectinib in patients with NTRK, ROS1, or ALK gene fusions?
What adverse events are reported in expanded access Entrectinib trials for fusion-positive cancers?
What are the competitive advantages of Entrectinib over other TRK/ALK/ROS1 inhibitors like Crizotinib or Lorlatinib?
Trial Locations
- Locations (1)
1-844-Startrk (782-7875)
🇺🇸San Diego, California, United States
1-844-Startrk (782-7875)🇺🇸San Diego, California, United States