Risk Taking and Decision-making in Cluster Headache Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 140
- 试验地点
- 1
- 主要终点
- Difference in mean total score on the Zuckerman Sensation Seeking Scale between groups
研究概览
简要总结
Since there is conflicting and insufficient data regarding CH personality and addictive behaviour, the investigators will investigate risk- and reward seeking behaviour in people with cluster headache. If an increased tendency towards this behaviour is shown, it will add to the clinical knowledge of cluster headache and possible lead to insights in a common biological susceptibility.
详细描述
Cluster headache is a severe primary headache disorder. In clinical anecdotes, people with cluster headache frequently report use of tobacco and illicit drugs. Furthermore, addictive behaviours and tattoos are considered to be more common in people with cluster headache than in the general population. The causality of these associations remains unclear. A common biological susceptibility has been proposed, predisposing people to both addictive behaviour and cluster headache. On the other hand, a role of illicit drug exposure in cluster headache pathophysiology has been suggested. The increased use of tobacco and illicit drugs could also reflect attempts to treat cluster headache attacks. In this explorative study the investigators will assess both subjective and objective measures reflecting addictive behaviour and risk- and reward seeking in cluster headache. This will add to the clinical knowledge of cluster headache and possible lead to insights in a common biological susceptibility.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age 18-64 years
- •Normal or corrected vision with acuity up to 20/60
- •Presence of episodic (n=35) or chronic (n=35) cluster headache or migraine with or without arua (n=35), diagnosed according to the International Classification of Headache Disorders criteria, 3rd edition (ICHD-3, 3.1.1)
排除标准
- •Diagnosis of uncorrected visual problems (myopia/presbiopia, peripheral vision problems or legal blindness)
- •Current diagnosis of generalized anxiety disorder, depression or other psychiatric illness
- •Other acute, unstable medical conditions or serious chronic diagnoses
结局指标
主要结局
Difference in mean total score on the Zuckerman Sensation Seeking Scale between groups
时间窗: One time-point
Between group difference
Difference in mean total number of pumps during second trial between groups
时间窗: One time-point
Between group difference
次要结局
- Difference in mean scores on the array of psychometric tests between groups(One time-point)
- Difference in mean scores on the BART between groups and between the first and second BART within groups(One time-point)
研究者
RolfFronczek
MD, PhD
Leiden University Medical Center