High Flow Nasal Cannula Versus Non Invasive Positive Pressure Ventilation in Reducing The Rate of Reintubation

Not Applicable

Not yet recruiting

• Conditions: Respiratory Failure; Re-intubation Rate
• Interventions: Device: high flow nasal cannula; Device: non invasive positive pressure ventilation

• Registration Number: NCT06029699
• Lead Sponsor: Assiut University

Brief Summary

This is study aim to compare between high flow nasal canula (HFNC) and non invasive positive pressure ventilation (NIPPV) in reducing the rate of reintubation in mechanically ventilated patient with successful weaning

Detailed Description

* High-flow nasal cannula (HFNC) oxygen therapy comprises an air/oxygen blender, an active humidifier, a single heated circuit, and a nasal cannula. It delivers adequately heated and humidified medical gas at up to 60 L/min of flow and is considered to have a number of physiological effects: reduction of anatomical dead space, positive end expiratory pressure ( PEEP ) effect, constant fraction of inspired oxygen, and good humidification

* Noninvasive positive-pressure ventilation is a safe and effective means of improving gas exchange in patients with many types of acute respiratory failure . for example, adding noninvasive ventilation to standard therapy decreased the need for endotracheal intubation...For patients assigned to noninvasive ventilation, the ventilator was connected with conventional tubing to a clear, full-face mask with an inflatable soft-cushion seal and a disposable foam spacer to reduce dead space .After the mask had been secured, pressure support was increased to achieve an exhaled tidal volume of 8 to 10 ml per kilogram, a respiratory rate of fewer than 25 breaths per minute, the disappearance of accessory muscle activity (as evaluated by palpation of the sternocleidomastoid muscle), and patient comfort

* The effects of high-flow nasal cannula (HFNC) on adult patients with acute respiratory failure (ARF) are controversial. The investigators aimed to further determine the effectiveness of HFNC in reducing the rate of endotracheal intubation in adult patients with ARF by comparison to noninvasive positive pressure ventilation (NIPPV)

Study Timeline

• Study First Submitted: 2023-08-25
• Status Verified: 2023-09
• Study First Submitted QC: 2023-09-07
• Last Update Submitted: 2023-09-07
• Study First Posted: 2023-09-08
• Last Update Posted: 2023-09-08
• Study Start: 2023-10-01
• Primary Completion: 2024-10-01
• Study Completion: 2026-10-01

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• All patient suffer from acute respiratory failure and intubated for mechanical ventilation and then extubated for weaning
• Age >18 years old

Exclusion Criteria

• In patients less than 18 years old
• Any contradiction in using HFNC as trauma or surgery or obstruction of nasopharynx
• Any contradiction in using NIPPV as facial trauma ..surgery ..deformity..or upper airway obstruction or upper gastrointestinal bleeding or high risk of aspiration

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
high flow nasal cannula group	high flow nasal cannula	patients put on high flow nasal cannula after extubation
non invasive positive pressure ventilation group	non invasive positive pressure ventilation	patients put on non invasive positive pressure ventilation group after extubation

Primary Outcome Measures

Name	Time	Method
the need for re-intubation and weaning success which will be measured by arterial blood gas ( ABG )	baseline

Secondary Outcome Measures

Name	Time	Method
Duration of using of HFNC or NIPPV	up to 30 days
Length of hospital stay measured by days	up to 30 days
Incidence of any possible complications associated with the use of HFNC and NIPPV	up to 30 days
In - hospital mortality measured by number of died cases	up to 30 days
Adverse events	up to 30 days	Adverse events (occurrence of nosocomial pneumonia based on clinical and laboratory and radiological finding, need for MV measured by re-intubation rate)