Effects of acute exercise on acetylcarnitine concentration in endurance trained- and untrained subjects

Completed

• Conditions: inactivity; Insulin resistance; 10018424

• Registration Number: NL-OMON37450
• Lead Sponsor: Academisch Ziekenhuis Maastricht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 13

Inclusion Criteria

- Age 18-40 years
- Normal weight (BMI 18-25 kg/m2)
- Healthy
- Stable dietary habits
- No use of medication
- VO2-max for trained subjects above 50 mL/min/kg
- VO2-max for untrained subjects below 40 mL/min/kg

Exclusion Criteria

- Any medical condition requiring treatment and/or medication use OR diminishing exercise tolerance
- Alcohol consumption of more than 20 g per day (± 2 units)
- Unstable body weight (weight gain or loss > 3 kg in the past three months)
- Participation in another biomedical study within 1 month prior to the screening visit
- Contraindications for MRI scan
* Central nervous system aneurysm clips
* Implanted neural stimulator
* Implanted cardiac pacemaker of defibrillator
* Cochlear implant
* Iron- containing corpora aliena in the eye or brain
* Hearing aids and artificial (heart) valves which is contraindicated for MRS

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Exercise-induced changes in acetylcarnitine concentrations and dynamics of<br /><br>acetylcarnitine restoration after exercise</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>* Substrate oxidation<br /><br>* Blood plasma levels of FFA, triglycerides, glucose and catecholamines</p><br>