Markers of neurodegeneration and oxidative stress and speed of progression in multiple sclerosis

• Conditions: multiple sclerosis; 10012303

• Registration Number: NL-OMON30350
• Lead Sponsor: niversitair Medisch Centrum Groningen

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 18 June 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 180

Inclusion Criteria

- age of eightteen years or older
- written informed consent
- MS-patients: a diagnosis of multiple sclerosis, according to the McDonald-criteria.

Exclusion Criteria

- contraindication for taking a blood sample

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>- The correlation of the measured biomarkers and skin autofluorescence with the<br /><br>porgression of disability (as measured with the EDSS and MSSS scales) over a<br /><br>period of five and ten years</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>- The correlation of the measured variables with fatigue (measured with the FSS<br /><br>scale)<br /><br>- The difference in the measured variables between MS-patients and healthy<br /><br>control persons</p><br>