Effect of different anesthetic techniques on inflammatory markers in patients undergoing major orthopedic trauma surgery
Not Applicable
- Conditions
- Health Condition 1: S723- Fracture of shaft of femur
- Registration Number
- CTRI/2020/01/022682
- Lead Sponsor
- AIIMS
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1.Male or female arriving in OT for pelvic-acetabular injury and fracture shaft femur.
2.More than18- 60 years of age.
3.ASA Grade I/II patients i.e. with minimal risk of anesthesia as per standard practices.
Exclusion Criteria
1.A Signs of infection present.
2.History of being operated within 3 months for any ailment.
3.Any allergy to anesthetic/ local anesthetic drugs.
4.Redo surgery.
5.Patient on immunosuppressant therapy.
6.History of inflammatory disorder.
7.Patients with difficult airway requiring fiber-optic intubation.
8.Contraindication to regional anesthesia i.e.platelet count < 80,000/cmm or PT INR > 1.5
9.Spine pathology present.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Influence of anesthetic technique on neutrophil extracellular trap & histone and stablish the diagnostic ability of NETs and Histone to early diagnosis of SIRS in major orthopedic trauma patients.Timepoint: 5 years
- Secondary Outcome Measures
Name Time Method 1.Quantification of NETs, histone and pro/anti-inflammatory cytokines at consecutive time points after major orthopedic surgery. <br/ ><br>2. Optimal timing for nonlife-saving surgical interventions after trauma. <br/ ><br>3. Damaged tissue healing and repair. <br/ ><br>4. Second hit related MOF. <br/ ><br>5. Hospital stay.Timepoint: 5 years