Prognostic Value of Sympathetic Modulation in Patients With Heart Failure

• Conditions: Heart Failure

• Registration Number: NCT02047409
• Lead Sponsor: University of Sao Paulo General Hospital

Brief Summary

The purpose of this study is to determine whether oscillatory pattern of sympathetic nerve activity muscle is an efficient index for the prognosis of patients with heart failure.

Detailed Description

Not available

Study Timeline

• Study Start: 2013-10
• Study First Submitted: 2014-01-24
• Study First Submitted QC: 2014-01-27
• Study First Posted: 2014-01-28
• Status Verified: 2015-09
• Last Update Submitted: 2015-09-18
• Last Update Posted: 2015-09-22
• Primary Completion: 2016-10
• Study Completion: 2016-10

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 160

Inclusion Criteria

• Patients with systolic heart failure and New York Heart Association (NYHA)
• Ischemic, hypertensive, or idiopathic etiology
• Left ventricular ejection fraction less than 40%

Exclusion Criteria

• Neuromuscular, Orthopedic, Neurologic and Pulmonary Diseases
• Renal failure
• Diabetes mellitus type II

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Peripheral autonomic control	12 months	Evaluate if the reduction in the oscillatory pattern of muscle sympathetic nerve activity is associated with morbidity and mortality in patients with heart failure in a clinical follow-up 12 months

Secondary Outcome Measures

Name	Time	Method
Functional Capacity	12 months
Arterial baroreflex control	12 months
Blood inflammatory markers	12 months
Cardiac and peripheral autonomic control	12 months

Trial Locations

Locations (1)

Heart Institute (InCor), University of Sao Paulo, School of Medicine.; 🇧🇷 São Paulo, Brazil