Ocular Penetration of Topical Tacrolimus Eye Drops
- Registration Number
- NCT02794610
- Lead Sponsor
- The Eye Center and The Eye Foundation for Research in Ophthalmology
- Brief Summary
Investigators aim to evaluate the ocular penetration of topical tacrolimus 0.03% eye drops.
Topical tacrolimus 0.03% will be instilled into the eyes of patients 15 minutes before cataract surgery. Aqueous samples will be collected at the time of cataract surgery and will be subjected to detection of presence and level of tacrolimus.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 10
Inclusion Criteria
- Any age or gender
- Patients scheduled for routine cataract surgery
- Clear healthy cornea
Exclusion Criteria
- Corneal pathology
- Ocular surface disease
- Intraocular inflammation
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Topical tacrolimus Tacrolimus Ten patients will be include. Topical tacrolimus 0.05% will be instilled into the eyes of patients 15 minutes before cataract surgery. Aqueous samples will be collected at the time of cataract surgery and will be subjected to detection of presence and level of tacrolimus.
- Primary Outcome Measures
Name Time Method Detection of the concentration of tacrolimus ( nanograms/milliliter) in the anterior chamber following ocular topical application. From date of obtaining the aqueous samples until getting the laboratory results of concentration of topical tacrolimus in the aqueous humor up to 2 months
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
The Eye Center
🇸🇦Riyadh, Saudi Arabia