The Role of Central Serotonergic and Adrenergic Systems in the Effectiveness of DNIC (Diffuse Noxious Inhibitory Control

Not Applicable

Completed

• Conditions: Healthy
• Interventions: Drug: Duloxetine

• Registration Number: NCT00660751
• Lead Sponsor: Rambam Health Care Campus

Brief Summary

The role of central serotonergic and adrenergic systems in the effectiveness of DNIC (Diffuse Noxious Inhibitory Control) will be tested before and after taking Duloxetine and Placebo in a double blind study.

Detailed Description

Not available

Study Timeline

• Study Start: 2007-08
• Study First Submitted: 2008-04-15
• Study First Submitted QC: 2008-04-16
• Study First Posted: 2008-04-17
• Primary Completion: 2012-04
• Study Completion: 2012-04
• Status Verified: 2017-10
• Last Update Submitted: 2017-10-10
• Last Update Posted: 2017-10-11

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 64

Inclusion Criteria

• Healthy volunteers
• age 18-80
• no chronic disease

Exclusion Criteria

• Subjects who suffer from chronic pain / pain syndrome
• use of anti-depressant or anti-psychotic drugs
• food/ drugs sensitivity
• breast feeding

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
1	Duloxetine	-
2	Duloxetine	-

Primary Outcome Measures

Name	Time	Method
level of DNIC	1 week

Trial Locations

Locations (1)

Rambam Health Care Campus; 🇮🇱 Haifa, Israel