Functional Connectivity In Relation To Proprioception and Sensorimotor Recovery in Stroke Patients (Feasibility Study)

University of Minnesota1 site in 1 country43 target enrollmentDecember 2015

ConditionsStroke

Overview

Phase: N/A
Intervention: Not specified
Conditions: Stroke
Sponsor: University of Minnesota
Enrollment: 43
Locations: 1
Primary Endpoint: Preliminary study to measure the brain mechanisms of cognitive multisensory rehabilitation
Status: Completed
Last Updated: 3 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

The purpose now is to:

identify brain connections related to proprioception to have a better understanding of differences between people with stroke and healthy persons
evaluate how these brain connections will change in people with stroke when they are engaged in 6-week cognitive multisensory rehabilitation.

Registry

clinicaltrials.gov

Start Date

December 2015

End Date

February 28, 2023

Last Updated

3 years ago

Study Type

Interventional

Study Design

Single Group

Sex

All

Investigators

Sponsor

University of Minnesota

Responsible Party

Sponsor

Eligibility Criteria

Inclusion Criteria

•Inclusion criteria for healthy subjects are:
•medically stable;
•18 - 99 years of age;
•able to hear the instructions given during the study
•Inclusion criteria for stroke patients are:
•at least 6 months post-stroke;
•medically stable;
•18 - 99 years of age;
•subcortical or cortical infarct confirmed with MRI;
•Mini-mental State Exam \> 24/30 (Folstein et al., 1975);

Exclusion Criteria

•having ever experienced a stroke or another brain injury or illness related to the brain that has lasting effects or effects experienced at the moment of recruitment;
•severe sensory impairments such that different movements of the finger, hand or wrist are not reliably felt;
•contractures in tested arm that hinder persons from keeping the outstretched arm in a relaxed position;
•interfering comorbidities (e.g. fracture, cancer, peripheral neuropathy);
•exhibit contra-indications to enter the magnetic field of the 3T (pacemakers, metal parts in the body etc);
•pregnant or nursing mother;
•adults lacking capacity to consent

Outcomes

Primary Outcomes

Preliminary study to measure the brain mechanisms of cognitive multisensory rehabilitation

Time Frame: 8 weeks

The robots will be used for research in healthy adults and stroke patients in the proposed studies below and are designed to mimick the exercises given during cognitive multisensory rehabilitation. The robots have been tested and cleared by the 3T safety committee at the CMRR, U of M. The first objective is a feasibility study to investigate the brain mechanisms of cognitive multisensory rehabilitation, through use of the robot in the 3T scanner at the U of M in healthy participants with stroke. Changes in brain function will be measured in individuals with stroke who will receive 8 weeks of therapy.