Association Between Age at Menopause and Levels of Anxiety and Depression
Overview
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Ankara City Hospital Bilkent
- Enrollment
- 136
- Locations
- 1
- Primary Endpoint
- Beck Anxıety Inventory (BAI), Anxiety level
Overview
Brief Summary
Menopause is defined as the permanent cessation of menstrual cycles due to ovarian follicle depletion, typically occurring after age 50, and is associated with decreased estrogen levels. Primary ovarian insufficiency (POI) involves early ovarian dysfunction before age 40, with infertility as a key concern. Both menopause and POI may contribute to psychological symptoms, including anxiety and depression, influenced by sociodemographic and health factors. While literature reports anxiety in middle-aged women, data on its association with menopausal timing are limited. This study aims to compare women with POI and those undergoing natural menopause after age 40, assessing the relationship between age at menopause, anxiety, and depression, as well as the impact of fertility expectations on psychological well-being in POI patients.
Study Design
- Study Type
- Observational
- Observational Model
- Case Control
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 24 Years to — (Adult, Older Adult)
- Sex
- Female
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Healthy women over 24 years of age who visited our hospital for routine outpatient check-ups, had been diagnosed with menopause, and had no history of psychiatric disorders before menopause.
Exclusion Criteria
- •Cardiovascular diseases including hypertension
- •Type 1 or type 2 diabetes mellitus
- •Morbid obesity
- •Primary adrenal insufficiency
- •Uterine fibroids
- •Thyroid dysfunctions including Hashimoto thyroiditis and Grave's disease
- •Hepatic dysfunctions
- •Renal insufficiency
- •Genetic disorders in chromosome constitution or karyotype analysis including monosomy X, trisomy X and gene mutations as BMP15, FMR I, POFIB, and GDF9
- •Neurologic diseases
Outcomes
Primary Outcomes
Beck Anxıety Inventory (BAI), Anxiety level
Time Frame: Baseline (single assessment at enrollment during routine clinic visit).
Anxiety severity measured by the Beck Anxiety Inventory (BAI) during routine clinic visit.
State-Trait Anxiety Scale (STAI) 1-2, Anxiety level
Time Frame: Baseline (single assessment at enrollment during routine clinic visit).
Anxiety severity measured by the State-Trait Anxiety Inventory (STAI) forms 1 and 2 during routine clinic visit.
Secondary Outcomes
No secondary outcomes reported
Investigators
Merve Didem Eşkin Tanrıverdi
Medical Doctor
Ankara City Hospital Bilkent