Effects of Periodontal Treatment in renal conditions

Phase 2

Recruiting

• Conditions: Periodontitis; Chronic Renal Insufficiency; C07.465.714.533; C12.777.419.780.750

• Registration Number: RBR-4dx6fk
• Lead Sponsor: niversidade Federal do Rio Grande do Sul

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2019-11-01
• Last Update Posted: 29 May 2023

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: Not specified

Inclusion Criteria

Stage 3 and 4 chronic kidney disease; Glomerular filtration rate lower than 60 ml / min / 1.73 m², without being in dialysis; Having more than 18 years of age; Not being HIV positive; Not having diagnosis, nor being in treatment of malignant neoplasia; Do not be pregnant or nursing; Moderate periodontitis according to the definition criteria of (2 or more interproximal sites with depth of probing of 5mm or more or 2 or more interproximal sites with loss of insertion of 4mm or more); Present at least 10 teeth present; Negative medical history of any systemic condition that necessitates the use of antimicrobial chemoprophylaxis.

Exclusion Criteria

Periodontal treatment in the last 6 months; Pregnant or breastfeeding.

Study & Design

• Study Type: Intervention
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The primary endpoint of the present study will be the glomerular filtration rate (GFR) measured in ml / min / 1.73m² based on both creatinine and cystatin C. This will be analyzed through the means and also the change of staging of each participant after treatment periodontal.

Secondary Outcome Measures

Name	Time	Method
Reduction in blood concentration of total cholesterol, LDL HDL, glycemia, glacial hemoglobin, triglycerides, creatinine, alkaline phosphatase, vitamin D, C-reactive protein, interleukin and tumor necrosis factor over time.