Short- and Long-Term Renal Outcomes Following Lung Transplantation- A Single-Centre Experience
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 120
- 试验地点
- 1
- 主要终点
- Impact of acute kidney injury (AKI) after lung transplantation on long-term renal function decline.
研究概览
简要总结
Evaluation of acute kidney injury, renal recovery and development of chronic kidney disease in patients undergoing lung transplantation
详细描述
It is well described that acute kidney injury and development of chronic kidney disease significantly impact short- and long-term survival after lung transplantation. However, there is limited data about prevalence of kidney disease according to current KDIGO consensus guidelines. It is the aim of this study to describe short- and long-term renal outcomes following lung transplantation. Selected patients who underwent prospective pretransplant renal functional reserve testing with high oral protein load will be analyzed separately in respect to occurrence of acute kidney injury following lung transplantation and development of chronic kidney disease.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Older than 18 years
排除标准
- •Patients with eGFR <15ml/min/1.73m2 or with chronic dialysis treatment prior LTx
- •Patients undergoing retransplantation and multiorgan transplantation
- •For prospective study involving patients with pretransplant renal functional reserve testing
- •Exclusion criteria:
- •unable to perform renal functional reserve testing (e.g., due to critical illness)
- •pre-existing acute kidney injury
结局指标
主要结局
Impact of acute kidney injury (AKI) after lung transplantation on long-term renal function decline.
时间窗: 7 days
AKI defined by KDIGO consensus criteria
次要结局
- Impact of sustained reversal versus non-recovery after AKI on long-term renal function decline after lung transplantation.(3 years)
- Risk factors associated with development of AKI and CKD after lung transplantation(3 years)
- Whether development of CKD is an independent risk factor for increased rejection rate and death after lung transplantation.(3 years)
- Association between pretransplant renal functional reserve with acute kidney injury after after lung transplantation.(7 days)
- Association between pretransplant renal functional reserve and renal function loss after lung transplantation.(1 year)
研究者
Faeq Husain
Senior Physician Nephrology
University of Giessen