Effects of levetiracetam, sodium valproate, and nortriptyline on migraine headaches
- Conditions
- Migraine headaches.Migraine
- Registration Number
- IRCT20140519017756N39
- Lead Sponsor
- Birjand University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 120
Presence of migraine headaches (headache attacks over 3 attacks per month; each attack with an interval of more than 48 hours of relief from other attacks)
Age from 18 to 65 years
Non-use of other anti-migraine drugs since at least one month ago
No allergy to levetiracetam, sodium valproate, and nortriptyline or their compounds
Absence of acute migraine resistant to treatment
Not having severe mental disorders
Absence of neurodegenerative disorders
No malignancy
Absence of pain disorders
No severe infection
Informed consent for participation
Pregnant or breast-feeding women
Irregular consumption of medications
Suffering from severe drug side-effects during the course of the study, which may change treatment regimen
Treatment-resistant acute migraine
Severe psychiatric disorders
Drug or alcohol dependence
Renal dysfunction
Excessive use of acute migraine drugs
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Headache severity. Timepoint: At the end of intervention. Method of measurement: Visual analogue scale.;Frequency of headache incidence. Timepoint: After intervention. Method of measurement: Patient daily notes during intervention.;Side effects (digestive, nervous, etc.). Timepoint: After intervention. Method of measurement: Patient daily notes during intervention.
- Secondary Outcome Measures
Name Time Method