In vivo Confocal Microscopic Analysis of Corneal Nerve And Inflammatory Cells in Patient with Keratoconus
- Conditions
- Study the corneal nerve characteristics and inflammatory cells in patient with Keratoconus.In vivo Confocal Microscopic, Corneal Nerve, Keratoconus
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 50
1. Thai men or women, healthy, aged 20-50 years
2. Not having a history of eye diseases. Including corneal surgery or previous corneal intervention that may affect the corneal nerves, including corneal inflammation, such as corneal ulcer, Herpes zoster infection, corneal injury, dry eye, glaucoma eye drops or undergoing glaucoma surgery, corneal dystrophy, bullous keratopathy, etc.
3. There are no physical diseases affecting the nerves throughout the body, including nerves that raise the cornea, such as diabetic mellitus, stroke and systemic neuropathy.
4. No diseases that cause inflammation throughout the body, including the eye (systemic inflammatory disease) such as autoimmune disease or septicemia.
5. Normal corneal sensation. Which was confirmed using a Cochet Bonnet esthesiometer.
1. Preliminary eye examination results found abnormalities of the cornea by a slit lamp biomicroscope including: Corneal abnormalities or abnormal cornea examination, Irregular eyes or blinking eyes, Irregular ocular surface, Irregular photoreceptor response, abnormal cornea sensitivity.
2. Blood glucose test results found to be diabetic or tend to have diabetes (impair glucose tolerance test)
3. Anaesthetic allergy
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Inflammatory cells and corneal nerve density Visit 0 HRT-III confocal microscopy
- Secondary Outcome Measures
Name Time Method Corneal nerve differentiation Visit 0 Compare corneal nerve density in between groups