Changes in Body- and Liver-composition During Low Calorie Diet in Morbidly Obese
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Liver volume
研究概览
简要总结
The purpose of this study is to determine what changes occur in body- and liver-composition during four weeks of low calorie diet in morbidly obese females
详细描述
Preoperative weight loss prior to laparoscopic gastric bypass is desirable as this reduces liver volume and thus facilitates the visualization of the gastro-esophageal junction. Weight loss is often achieved through low-calorie diet (LCD); however the ideal duration of LCD treatment is unknown.
Morbidly obese female patients awaiting laparoscopic gastric bypass are recruited. They are, as all our patients, treated during four weeks with LCD to achieve a decrease in liver size. During this period they are examined on day 0, 3, 7, 14 and 28 after commencing LCD.
At each evaluation, body composition is assessed through bioelectric impedance analysis (BIA), liver volume and intrahepatic fat through magnetic resonance imaging. A questionnaire regarding quality of life and LCD-related symptoms is administered as well. At surgery two samples of subcutaneous fat and one sample of omental fat is taken.
We do not assign patients to different treatments, instead all are treated similarly according to our routine preoperative regimen.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 20 Years 至 60 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Awaiting laparoscopic gastric bypass
- •Residing near Uppsala
排除标准
- •Weight above 140 kg
- •Metal implants such as pacemaker or intracerebral clips
- •Failure to understand or comply with study protocol
结局指标
主要结局
Liver volume
时间窗: From baseline to after four weeks
次要结局
- Changes in body composition(Baseline to 4 weeks)
- Composition of body fat in subcutaneous and omental fat(At surgery)
研究者
DEdholm
MD
Uppsala University