Effect of Induction and Maintenance of Anesthesia With Etomidate on Hemodynamics and Oxidative Stress in Diabetic Patients
- Conditions
- Oxidative StressHemodynamicsAnesthesia
- Interventions
- Registration Number
- NCT02202239
- Lead Sponsor
- Zhujiang Hospital
- Brief Summary
To explore the effect of induction and maintenance of anesthesia with etomidate on hemodynamics and oxidative stress in diabetic patients.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 60
- Aged between 18 and 65 years;
- Diabetic patients preparing for elective surgery;
- Body mass index is between 16 and 30 kg/m2;
- Blood glucose is under 8.3 mmol/kg by oral antidiabetic agents or diet control;
- American Society of Anesthesiology (ASA) Physical Status: Ⅰ or Ⅱ;
- Expected operation duration is between 2 and 8 h;
- Signed informed consent form.
- Severe cardiac, cerebral, liver, kidney, lung, endocrine disease or infectious disease;
- Chemotherapy or immunotherapy before the surgery;
- Allergy to trial drug or other contraindication;
- Expected or history of difficult airway;
- Suspected abuse of narcotic analgesia;
- Diseases of neuromuscular system;
- Mentally unstable or has a mental illness;
- Trend of malignant hyperthermia;
- Pregnant or breast-feeding women;
- Attendance of other trial past 30 days.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Group E Penehyclidine Hydrochloride Injection Etomidate was used in both induction and maintenance of anesthesia. Group P Cisatracurium Besilate Propofol was used in both induction and maintenance of anesthesia. Group E Cisatracurium Besilate Etomidate was used in both induction and maintenance of anesthesia. Group E Etomidate Etomidate was used in both induction and maintenance of anesthesia. Group E midazolam Etomidate was used in both induction and maintenance of anesthesia. Group E Fentanyl Etomidate was used in both induction and maintenance of anesthesia. Group P Propofol Propofol was used in both induction and maintenance of anesthesia. Group E Remifentanil Etomidate was used in both induction and maintenance of anesthesia. Group E Sevoflurane Etomidate was used in both induction and maintenance of anesthesia. Group P Sevoflurane Propofol was used in both induction and maintenance of anesthesia. Group P midazolam Propofol was used in both induction and maintenance of anesthesia. Group P Fentanyl Propofol was used in both induction and maintenance of anesthesia. Group P Remifentanil Propofol was used in both induction and maintenance of anesthesia.
- Primary Outcome Measures
Name Time Method Central venous pressure from 10 minutes before induction to 1 h after the surgery Central venous pressure will be measured 10 min before the induction (T0), at intubation (T1), 5 min (T2), 15 min (T3) after intubation, 30 min after the beginning of the surgery (T4) and 1 h after the end of the surgery.
Beginning of the surgery: beginning of skin incision. End of the surgery: skin suture is finished.Heart rate from 10 minutes before induction to 1 h after the surgery Heart rate will be recorded 10 min before the induction (T0), at intubation (T1), 5 min (T2), 15 min (T3) after intubation, 30 min after the beginning of the surgery (T4) and 1 h after the end of the surgery.
Beginning of the surgery: beginning of skin incision. End of the surgery: skin suture is finished.Respiratory rate from 10 minutes before induction to 1 h after the surgery Respiratory rate will be measured 10 min before the induction (T0), at intubation (T1), 5 min (T2), 15 min (T3) after intubation, 30 min after the beginning of the surgery (T4) and 1 h after the end of the surgery.
Beginning of the surgery: beginning of skin incision. End of the surgery: skin suture is finished.Oxygen saturation from 10 minutes before induction to 1 h after the surgery Oxygen saturation will be measured 10 min before the induction (T0), at intubation (T1), 5 min (T2), 15 min (T3) after intubation, 30 min after the beginning of the surgery (T4) and 1 h after the end of the surgery.
Beginning of the surgery: beginning of skin incision. End of the surgery: skin suture is finished.Mean arterial pressure from 10 minutes before induction to 1 h after the surgery Mean arterial pressure will be measured 10 min before the induction (T0), at intubation (T1), 5 min (T2), 15 min (T3) after intubation, 30 min after the beginning of the surgery (T4) and 1 h after the end of the surgery.
Beginning of the surgery: beginning of skin incision. End of the surgery: skin suture is finished.Blood glucose from 10 minutes before induction to 1 h after the surgery Blood glucose will be measured 10 min before the induction (T0), at intubation (T1), 15 min (T2) after intubation, 1 h after the beginning of the surgery (T3), when the surgery is finished (T4) and 1 h after the end of the surgery (T5).
Beginning of the surgery: beginning of skin incision. End of the surgery: skin suture is finished.Insulin from 10 minutes before induction to 1 h after the surgery Insulin will be measured 10 min before the induction (T0), at intubation (T1), 15 min (T2) after intubation, 1 h after the beginning of the surgery (T3), when the surgery is finished (T4) and 1 h after the end of the surgery (T5).
Beginning of the surgery: beginning of skin incision. End of the surgery: skin suture is finished.
- Secondary Outcome Measures
Name Time Method Super oxide dismutase from 10 minutes before induction to 1 h after the surgery 2 ml blood will be collected 10 min before the induction (T0), at intubation (T1), 5 min (T2), 15 min (T3) after intubation, 30 min after the beginning of the surgery (T4) and 1 h after the end of the surgery. The blood will be preserved below -20 ℃ before super oxide dismutase was measured.
Beginning of the surgery: beginning of skin incision. End of the surgery: skin suture is finished.Glutathione from 10 minutes before induction to 1 h after the surgery 2 ml blood will be collected 10 min before the induction (T0), at intubation (T1), 5 min (T2), 15 min (T3) after intubation, 30 min after the beginning of the surgery (T4) and 1 h after the end of the surgery. The blood will be preserved below -20 ℃ before glutathione was measured.
Beginning of the surgery: beginning of skin incision. End of the surgery: skin suture is finished.Xanthine oxidase from 10 minutes before induction to 1 h after the surgery 2 ml blood will be collected 10 min before the induction (T0), at intubation (T1), 5 min (T2), 15 min (T3) after intubation, 30 min after the beginning of the surgery (T4) and 1 h after the end of the surgery. The blood will be preserved below -20 ℃ before xanthine oxidase dismutase was measured.
Beginning of the surgery: beginning of skin incision. End of the surgery: skin suture is finished.