Open labelled, single arm clinical trial to evaluate the role of yashtimadhu moola churna as a medhya rasayan for improving short term memory in children of Age 12 to 16 years
试验速览
- 阶段
- 3 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 400
- 试验地点
- 1
- 主要终点
- Short Term Memory
研究概览
简要总结
| Ayurveda has duly recognized the individuality of Mana and Sharira and |
| their inseparable and interdependent relation in living body. Mana, Atma and Sharira together |
| leads to the Ayu of an individual. One who has |
| balanced Dosha, balanced Agni, and properly |
| formed Dhatus; proper elimination of Malas, |
| well-functioning bodily processes, and whose mind, soul and senses are full |
| of bliss is called a healthy person. Difference in the human and other |
| living species on the planet earth is the human brain. The human brain is |
| also responsible for the development of human in all aspect and for this |
| memory plays an important role. All living species learn everything by remembering |
| previous experience but humans are more developed than other because of the |
| intellect. Memory and Intelligence of human makes them superior in all |
| aspect, which changes the standard of living of humans from time to time. |
Ayurvedacoined the term Medhawhich means Dharana Shakti i.e. Intellectual and / or retention and Rasayanmeans therapeutic procedure or preparations that on regular practice which boost nourishment, health, memory, intellect, immunity and hence longevity.
The Ayurvedictexts describes a set of rejuvenate to impact biological sustenance to the bodily tissues. These remedies are called Rasayan which are claimed to act as micronutrients. Some of these Rasayanasare organ and tissue specific. Those specific to brain tissue are called Medhya Rasayan. Medhya Rasayanis a group of four medicinal plants that can be used singly or in combinations explained by Acharya Charakin first adhyayaof *Charaka Samhita Chikitsasthana i.e. Rasayan Adhyay.*In school life, children are more focused on the study to have the bright future in life. Students may mugging up the definitions, formulae or try to remember it by writing it on a paper so many times to get good grades or marks in the examination. Students will not get good marks by reading a book one day before exam, they need to study for a long period of time with consistency before any examination, and like this long term practice of Medhya Rasayan is required to enhance the memory.
Four medhya rasayan are explained by Acharya Charaka. Yashtimadhu is to taken in the form of churna and aupana is dugdha i.e. cow milk, which is considered to be palatable among all four medhya rasayan. Swaras of Mandukparni and Guduchi, kalka of Shankhapushpi is too explained as a medhya rasayan but swarasa and kalka are not as palatable as churnain children.
Yashtimadhu is commonly known as Kanthya and kanda i.e. bark is used for it in day today practice. So I have choose Yashtimadhu moola churna as a medhya rasayan for research study as the medhya karma of Yashtimadhu is neglected though it is explained in Charaka samhita.
Dhee, Dhrutiand Smruti definitions given by Chakrapanidatta in Ayurvedadipika, ArunadattainSarvangasundaraandHemadriinAyurvedarasayan, the word Smruti is relate with the word memory among Dhee, Dhruti and Smruti. Exam pattern in our education system is completely based on memory i.e. smaranshakti. So Yashtimadhu churnais selected for this research study out of four medhya rasayan dravyas because churna is palatable and anupana for it is milk thus it will be easy for the children to take the medicine on daily basis for 3 months of time period.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 盲法
- None
入排标准
- 年龄范围
- 12.00 Year(s) 至 16.00 Year(s)(—)
- 性别
- All
入选标准
- •Subjects of age 12 to 16 specifically school going children of standard 8th and 9th will be selected.
- •IQ score as per Malin’s Intelligence Scale for Indian Children (MISIC) in between 70 to
- •200 participants from Marathi medium school and 200 participants from English medium school will be selected.
- •Subjects will be selected irrespective of gender, religion, and socio-economical condition.
- •Parent of the subject who give informed written consent will be included.
排除标准
- •Subjects of age below 12 and above 16 specifically school going children of standard below 8th and above 9th will be excluded.
- •IQ score as per Malin’s Intelligence Scale for Indian Children (MISIC) below 70 and above
- •Subjects who are taking any authenticate memory enhancer drug or formulations will be excluded.
- •Subjects who are taking any treatment from psychiatrist for any mental problem will be excluded.
- •Subjects who stopped psychiatric treatment in last 3 months will be excluded.
- •Female participants having irregular menses, PCOS will be excluded.
结局指标
主要结局
Short Term Memory
时间窗: 90 Days
a. Auditory-verbal Short term memory test
时间窗: 90 Days
b. Visual-verbal Short term visual memory test for Numbers
时间窗: 90 Days
c. Visual-verbal Short term visual memory test for Words
时间窗: 90 Days
次要结局
- 1. Bala(2. Agni)
研究者
Ajay Shivajirao Thote
Yashwant Ayurvedic College Post Graduate Training and Research Centre Kodoli
