Lignocaine Nebulization versus Intravenous Lignocaine to suppress the hemodynamic response to Laryngoscopy and Tracheal Intubation: A Comparative Study
试验速览
- 阶段
- 4 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 90
- 试验地点
- 1
- 主要终点
- To study the haemodynamic response during laryngoscopy and endotracheal intubation.
研究概览
简要总结
The present study is a Prospective , Randomized and comparative study done after the approval of Institutional Ethics Committee in patients aged 18-45yrs of age satisfying all inclusion and exclusion criteria planned for elective surgery under GA. Materials used will be 4% lignocaine , 2% xylocard , nebulization mask , Anesthesia workstation , multipara monitor, suction apparatus , IV fluids , emergency drugs, Laryngoscope and Endotracheal tubes of various sizes.
The patients will be randomly allocated into 3 groups. Group 1 will be nebulized with 2ml of 4% lignocaine and 3ml of NS + 4ml IV normal saline will be given . Group 2 will be nebulized with normal saline 5ml + 4ml iv 2% xylocard will be given. Group 3 will be nebulized with NS 5ml + 4ml NS IV will be given. The parameters such as SBP, DBP, MAP, HR, and SPO2 will be recorded as baseline before starting nebulization at T0 and then every 5 minutes during nebulization . After 30 min of nebulization patient will be taken inside the operation theatre and all non invasive monitors will be attached. Airway will be secured with appropriately sized cuffed endotracheal tube and the parameters such as SBP, DBP, MAP, HR, Oxygen saturation will be recorded before laryngoscopy , immediately after intubation , 1 minute after intubation and every 5 minutes after intubation for 20 minutes.
Effect of nebulized versus intravenous lignocaine will be compared to suppress the hemodynamic response to laryngoscopy and tracheal intubation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Coin toss, Lottery, toss of dice, shuffling cards etc
- 盲法
- Participant and Outcome Assessor Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 45.00 Year(s)（—）
- 性别
- All
入选标准
- •patient giving consent
- •all patients aged 18-45yrs
- •ASA grade 1&2
- •both genders 5.hemodynamically stable patients
- •patients undergoing elective surgical procedures under GA
- •patient not receiving any vasoactive drugs.
排除标准
- •Patient refusal for giving consent
- •Patient who already received lignocaine by any route.
- •Hypersensitivity to lignocaine.
- •History of convulsions.
- •Patient receiving vasoactive drug support.
- •Patient on mechanical ventilation with endotracheal or tracheostomy tube.
- •Patients with anticipated difficult airway.
- •Patients having history of laryngeal, tracheal surgery or any pathology.
结局指标
主要结局
To study the haemodynamic response during laryngoscopy and endotracheal intubation.
时间窗: 20-30 minutes
次要结局
- 1.To evaluate the complication associated with nebulization vs intravenous lignocaine.(2.To evaluate the suppression of arrhythmia if any during laryngoscopy and intubation.)
研究者
Dr Shipra Chandra
Government Medical College, Haldwani