Study on clinical mechanism of acupuncture for soothing liver and regulating mind on brain plasticity in population with generalized anxiety disorder under epidemic situatio
- Conditions
- Generalized anxiety disorder
- Registration Number
- ITMCTR2200006844
- Lead Sponsor
- Shenzhen Bao'an Traditional Chinese Medicine Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- All
- Target Recruitment
- Not specified
Inclusion criteria of GAD patients under epidemic situation:
( 1 ) Patients who met the above diagnostic criteria of generalized anxiety disorder in Chinese and Western medicine and were diagnosed in the context of the new coronavirus epidemic ;
( 2 ) Hamilton Anxiety Scale ( HAMA ) 14 determination = 14 points and < 29 points ;
( 3 ) Age = 18 years, = 65 years ;
( 4 ) those who have not received medication, physical or psychological treatment in the past three weeks, or those in stable condition ;
signed informed consent and volunteered to participate in this study.
Inclusion criteria for healthy people:
(1) Age = 18, = 65;
(2) Right handed, regardless of gender;
(3) He has been in good health without any discomfort in the past month;
(4) No central stimulation (rTMS, TDCS, etc.) or peripheral stimulation (acupuncture, transcutaneous electrical stimulation, etc.) in recent 3 months; (5) No history of illegal drug use and excessive drinking;
(6) Those who signed the informed consent form and volunteered to participate in the study.
Exclusion criteria for GAD patients under epidemic situation:
( 1 ) Patients who do not meet the inclusion criteria ;
( 2 ) patients with a history of brain trauma, epilepsy, or accompanied by liver and kidney dysfunction, metal implants or severe physical organic diseases such as cardiovascular, cerebrovascular, liver and kidney ;
( 3 ) Patients with other anxiety symptoms of schizophrenia, bipolar disorder or other mental disorders, physical illness ;
( 4 ) Patients with previous or current suicide plan or behavior, psychotic symptoms or anxiety caused by alcohol, drug abuse or withdrawal after addiction ;
( 5 ) Patients with poor compliance or fear of acupuncture ;
( 6 ) Left-handed ;
( 7 ) Pregnant and lactating women.
Exclusion criteria for healthy population:
(1) People with speech disorder;
(2) Hypertension, diabetes and major heart, liver, kidney and other organ diseases; (3) Have a history of dementia, psychosis, epilepsy and other neurological diseases;
(4) History of craniocerebral trauma and operation;
(5) There are metal residues in the body (including dentures, pacemakers, nerve stimulators, medical pumps, etc.); (6) Those who are afraid of TMS and are unable to perform TMS stimulation for other reasons;
(7) Pregnant women.
Study & Design
- Study Type
- Interventional study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Transcranial magnetic stimulation detection ( rMT, MEP, CSP and PAS10, PAS25 );Related Scale Assessment ( Hamilton Anxiety Scale, State-Trait Anxiety Questionnaire );
- Secondary Outcome Measures
Name Time Method Peripheral blood tests, including: 5-hydroxytryptamine (5-HT), glutamic acid (Glu), glutamamide (Gln), gamma-aminobutyric acid (GABA), brain-derived neurotrophic factor (BDNF);