Schizophrenia and PTSD Project: Health, Interventions, and Risk/Resilience Evaluation(SAPPHIRE Study)
- Conditions
- SchizophreniaPTSD
- Registration Number
- NCT00560677
- Lead Sponsor
- Durham VA Medical Center
- Brief Summary
We propose to establish a database characterizing the presence or absence of comorbid PTSD in veterans with schizophrenia or schizoaffective disorder (SAD) receiving services at the Durham VA Medical Center. In addition to the evaluation of PTSD symptoms in veterans with schizophrenia or SAD, this database will facilitate the investigation of a number of additional specific research questions relevant to veterans with psychotic disorders.
- Detailed Description
See brief summary
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 400
- 18-72 years of age, any ethnic group, either sex.
- Diagnostic and Statistical Manual, Fourth Edition (DSM-IV) diagnosis of schizophrenia or schizoaffective disorder.
- Ability to fully participate in the informed consent process, or have a legal guardian able to participate in the informed consent process.
- Unstable current medical or neurological illness.
- Significant suicidal or homicidal ideation.
- Pregnant women or women who could be pregnant.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Brief Assessment of Cognition in Schizophrenia (BACS) Visit 1 The Brief Assessment of Cognition in Schizophrenia (BACS) includes brief assessments of executive functions, verbal fluency, attention, verbal memory, working memory and motor speed. Z-scores are calculated from composite scores. Higher z-scores are indicative of better cognitive performance, lower z-scores are indicative of lower cognitive performance. Range of z-scores anticipated to be between -3 and 3.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Durham VAMC
🇺🇸Durham, North Carolina, United States