Predicting Outcome and Measuring Benefit from botulinum therapy in Stroke

Phase 2

Completed

• Conditions: Topic: Stroke Research Network; Subtopic: Rehabilitation; Disease: Drug type, Therapy type, In hospital study; Circulatory System; Stroke

• Registration Number: ISRCTN03624752
• Lead Sponsor: niversity College London (UK)

Brief Summary

2014 results in: http://discovery.ucl.ac.uk/id/eprint/1459867 2020 results in https://pubmed.ncbi.nlm.nih.gov/31747825/ (added 23/04/2021)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2010-05-12
• Study Completion: 2013-12-31
• Last Update Posted: 3 May 2021

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 28

Inclusion Criteria

1. Clinically confirmed diagnosis of stroke
2. More than 1 month post-stroke
3. An Ashworth score of 2 or more
4. The ability to pick up a mug and move it to another position (so that participants are able to use any improvement in hand control in functional reach and grasp tasks)
5. Aged 18 years and over (no max), both male and female participants

Exclusion Criteria

1. Orthopaedic impairments affecting the hemiplegic upper limb or spine
2. Additional neurological impairment not related to stroke
3. Shoulder or wrist pain (greater than 3 on a 0 - 10 visual analogue scale) whilst performing the experimental tasks
4. Severe cognitive impairment preventing informed consent and/or the ability to follow task instructions
5. Anti-coagulation with an international normalised ratio (INR) of greater than 2

Study & Design

• Study Type: Interventional
• Study Design: Not specified