Polycystic ovarian syndrome & Chronic Periodontitis
- Conditions
- Health Condition 1: R888- Abnormal findings in other body fluids and substancesHealth Condition 2: E282- Polycystic ovarian syndrome
- Registration Number
- CTRI/2019/09/021214
- Lead Sponsor
- SERB DST
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Women between 18 and 30 years of age.
2. PCOS diagnosis will be based on the criteria by Rotterdam2 with the presence of at least two of the following: polycystic ovaries, oligomenorrhea and/or anovulation, hyperandrogenism (clinical and/or biochemical)
3. Diagnosis of generalized moderate-to-severe chronic periodontitis will be based on presence of at least 20 teeth in the oral cavity, with at least 30% of the areas undergoing clinical attachment loss of at least 3 mm and a probing depth of >=5 mm and radiographic evidence of bone loss3.
4. The systemically healthy group will be based on; history of regular menstrual cycles, no clinical or biochemical sign of hyperandrogenism, matching with the PCOS group in body mass index (BMI) and exclusion of PCOS by ultrasound examination.
5. Willingness to sign consent for study including participation with collection of blood specimens
6. Willingness to discontinue OCP for duration of study period up to 18 weeks
Pregnancy
2. History of smoking or any drug usage, including oral contraceptives, systemic antibiotics (during the previous 6 months) or continuous use of NSAIDs
3. History of any dental treatment in the previous six months.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method to obtain an association between PCOS and chronic periodontitis <br/ ><br>To assess and compare serum and salivary bone marker levels in PCOS subjects with or without periodontitis before and after non surgical periodontal therapy <br/ ><br>To assess and compare bone density levels in PCOS subjects with or without periodontitis before and after non surgical periodontal therapyTimepoint: 0-18 Months
- Secondary Outcome Measures
Name Time Method serum testorone levels among PCOD females <br/ ><br>effect of non surgical periodontal therapy on pros symptoms <br/ ><br>bone marker levels in saliva and serumTimepoint: baseline to six months